产品货号：
GS4480
中文名称：
重组大鼠IL-13
英文名称：
Recombinant Rat Interleukin 13
产品规格：
2μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 12.2kDa,a single non-glycosylated polypeptide chain containing 111 amino acids.
储存条件：冷冻（-20℃）
概述
Interleukin-13(IL-13)is expressed by the IL13 gene and secreted by many cell types,especially T helper type 2(Th2)cells.The high solution from of IL-13 reported to be a monomer with two internal disulfide bonds that contribute to a bundled four α-helix configuration.Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites.IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1beta,TNF-alpha,IL-6 and IL-8.IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE.Mature rat IL-13 shares 59%,75%,and 60%amino acid sequence identity with human,mouse,and rhesus IL-13,respectively.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组大鼠IL-13，IL-13, Rat，Recombinant Rat Interleukin 13
储存条件：冷冻（-20℃）
概述
Interleukin-13(IL-13)is expressed by the IL13 gene and secreted by many cell types,especially T helper type 2(Th2)cells.The high solution from of IL-13 reported to be a monomer with two internal disulfide bonds that contribute to a bundled four α-helix configuration.Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites.IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1beta,TNF-alpha,IL-6 and IL-8.IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE.Mature rat IL-13 shares 59%,75%,and 60%amino acid sequence identity with human,mouse,and rhesus IL-13,respectively.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞97%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 4ng/ml,corresponding to a specific activity of>2.5×105 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4. |
| 内毒素 | Less than 1 EU/μg of rRtIL-13 as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20?C.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | MPVRRSTSPP VALRELIEEL SNITQDQKTS LCNSSMVWSV DLTAGGFCAA LESLTNISSC NAIHRTQRIL NGLCNQKASD VASSPPDTKI EVAQFISKLL NYSKQLFRYG H |
相关搜索：重组大鼠IL-13，IL-13, Rat，Recombinant Rat Interleukin 13